WATERTOWN, Mass., Aug. 04, 2020 (GLOBE NEWSWIRE) -- Lyra Therapeutics, Inc. (Nasdaq: LYRA), a clinical-stage therapeutics company focused on the development and commercialization of novel integrated drug and delivery solutions for the localized treatment of patients with ear, nose and throat diseases, today announced the appointment of Pamela Nelson to the position of Senior Vice President of Regulatory Affairs. Pamela brings with her more than 25 years of experience in the biotechnology industry, with regulatory expertise in drugs and drug/device combination products across a range of therapeutic areas.

“I am excited to welcome Pamela to Lyra Therapeutics, where she will play an important role in helping us obtain regulatory approval for our late stage chronic rhinosinusitis drug candidates,” said Maria Palasis, Ph.D., President and CEO of Lyra Therapeutics. “Her experience in regulatory affairs involving both drug and drug/device combinations makes her especially suited for Lyra as we advance our late stage CRS programs and broaden our pipeline into new indications.”

“I am delighted to be joining Lyra. I believe the company has not only assembled a strong development pipeline, but also the right people to move drugs candidates through clinical trials, to regulatory approval, and finally into commercialization,” said Pamela Nelson, Senior Vice President of Regulatory Affairs at Lyra Therapeutics. “I look forward to working with the Lyra team and helping to bring a range of much needed therapeutics to the patients who need them.”

Before joining Lyra, Pamela served as Vice President, Regulatory Affairs at Avedro, where she successfully led the company’s regulatory efforts for its first drug/device combination product from development, through FDA approval, and into commercial launch. Previously, she held regulatory positions at Alnara Pharmaceuticals, Altus Pharmaceuticals, Alkermes and Genzyme. Ms. Nelson holds a bachelor’s degree in english and a master’s degree in education administration from the University of Massachusetts at Amherst.

About Lyra Therapeutics

Lyra Therapeutics, Inc. is a clinical-stage therapeutics company focused on the development and commercialization of novel integrated drug and delivery solutions for the localized treatment of patients with ear, nose and throat diseases. The company’s proprietary technology platform, XTreo™, is designed to precisely and consistently deliver medicines directly to the affected tissue for sustained periods with a single administration. The company’s initial product candidates, LYR-210 and LYR-220, are bioresorbable polymeric matrices designed to be administered in a brief, non-invasive, in-office procedure and intended to deliver up to six months of continuous drug therapy to the sinonasal passages for the treatment of chronic rhinosinusitis (CRS). The therapeutic embedded within LYR-210 and LYR-220 is mometasone furoate, which is the active ingredient in various FDA-approved drugs and has a well-established efficacy and safety profile. CRS is an inflammatory disease of the paranasal sinuses which leads to debilitating symptoms and significant morbidities and affects approximately 14 million people in the United States. The company is advancing LYR-210 as a potential preferred alternative to surgery in an ongoing Phase 2 clinical trial for CRS patients who have failed medical management. In its Phase 1 clinical trial, LYR-210 met its primary safety endpoint, and it was observed that patients generally experienced significant and rapid, clinically meaningful and durable improvement in SNOT-22 scores, an established patient symptom severity scale, through week 25, which was the end of the trial. The company is also developing LYR-220 for use in CRS patients who have an enlarged nasal cavity due to sinus surgery but continue to require treatment to manage CRS symptoms. Beyond CRS, the company believes its XTreo platform has potential applications in other disease areas, which it is actively exploring to further broaden the platform’s therapeutic potential.

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