Proteostasis Therapeutics, Inc. (NASDAQ:PTI), a clinical stage biopharmaceutical company dedicated to the discovery and development of groundbreaking therapies to treat cystic fibrosis (CF) and other diseases caused by dysfunctional protein processing, today announced that Badrul A. Chowdhury, M.D., Ph.D., has been appointed to the Company's Board of Directors. Dr. Chowdhury is Senior Vice President and Chief Physician-Scientist, Respiratory Inflammation and Autoimmunity (RIA) Late Stage, R&D Biopharmaceuticals, at AstraZeneca. He was previously Director of the Division of Pulmonary, Allergy, and Rheumatology Products at the U.S. Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER).

"Dr. Chowdhury has deep expertise as a regulatory strategist, including having presided over the FDA approvals of the current standard-of-care CFTR modulators. With a broad view across many diseases, including CF, his counsel will be invaluable to PTI as we advance our CF pipeline toward launching our Phase 3 program in mid-2020. We are thrilled to welcome him to the PTI board of directors," said Meenu Chhabra, President and Chief Executive Officer of Proteostasis.

"With its next generation CFTR modulators, Proteostasis has demonstrated the promise of becoming a highly-credible new entrant into the CF marketplace," commented Dr. Chowdhury. "The CF community has a resounding need for more options to address issues that include patient access, tolerability and durability of treatment. I look forward to contributing as a director to PTI's mission of bringing more treatment options to patients with cystic fibrosis."

Dr. Chowdhury practiced medicine for more than a decade and has more than two decades of regulatory leadership experience. Prior to joining AstraZeneca in April 2018, Dr. Chowdhury served at the FDA for 21 years, where he held numerous leadership roles. His previous roles at the FDA include Medical Team Leader, Division of Pulmonary and Allergy Drug Products, CDER, and Medical Officer, Division of Pulmonary Drug Products, CDER. Dr. Chowdhury has a M.B., B.S. in Medicine from University of Dhaka, Dhaka Medical College, Bangladesh, and a Ph.D. in Immunology from Memorial University of Newfoundland, Canada. He completed his residency training in Internal Medicine at the Wayne State University School of Medicine, Detroit, Michigan, and a fellowship in Allergy and Immunology at the National Institutes of Health's, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, and is double board certified in Internal Medicine and Allergy and Immunology.

About Proteostasis Therapeutics, Inc.

Proteostasis Therapeutics, Inc. is a clinical stage biopharmaceutical company developing small molecule therapeutics to treat cystic fibrosis and other diseases caused by dysfunctional protein processing. Headquartered in Boston, MA, the Proteostasis Therapeutics team focuses on identifying therapies that restore protein function. For more information, visit www.proteostasis.com.